理研

次世代ヒト疾患モデル研究開発チーム

次世代ヒト疾患モデル研究開発チーム

japanese

Publication

  • Yoshida K, Takada T, Muratani M and Amano T.
    Allele-specific gene expression in F1 hybrid mice reveals structural variants affecting macrophage characteristics.
    Scientific Reports, 15, 1, 37846. (2025). 
  • Dinh TTH, Imura C, Shiokawa M, Ayabe S, Yoshiki A, Inoue H and Amano T.
    “A partial deletion of the Tardbp 3´UTR affects TDP-43 regulation and leads to motor dysfunction in mice”
    Experimental Animals 75, 1, 25-61. (2025).
  • Hang A, Shao A, Shea M, Roux MJ, Imai-Leonard DM, Adams DJ, Amano T, Amarie OV, Berberovic Z, Bour R, Bower L, Leonard BC, Brown SD, Cho SY, Clementson-Mobbs S, D’Souza AJ, Dickinson M, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Heaney J, Hérault Y, Hrabe de Angelis M, Hsu CW, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Salazar J, Seavitt JR, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T,  Sorg T, Stewart M, Tamura M, Tolentino H, Udensi U, Wells S, Wurst W, Yoshiki A, Meziane H, Yiu G, Sieving PA, Lanoue L, Lloyd KCK, McKerlie C and Moshiri A; International Mouse Phenotyping Consortium (IMPC).
    Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes.
    Investigative Ophthalmology & Visual Science, 66, 6, 64. (2025). 
  • Rahmawati NY, Dinh TTH, Oikawa T, Shinogi A, Ikeda K, Kadota M, Tamura M, Amano T and Yoshiki A.
    “Luminescent mouse model of endometriosis: three-dimensional morphology of lesions and cytokine profiles”
    Experimental Animals 74, 4, 419-428. (2025). 
  • Briere A, Vo P, Yang B, Adams D, Amano T, Amarie O, Berberovic Z, Bower L, Brown SDM, Burrill S, Cho SY, Clementson-Mobbs S, D’souza A, Eskandarian M, Flenniken AM,     Fuchs H, Gailus-Durner V, Hérault Y, Hrabe de Angelis M, Jin S, Joynson R, Kang YK,    Kim H, Masuya H, Meziane H, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Salazar J, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Stewart M, Svenson K, Tamura M, Tolentino H, Wells S, Wurst W, Yoshiki A, Lanoue L, Lloyd KCK, Leonard BC, Roux MJ, McKerlie C and Moshiri A; International Mouse Phenotyping Consortium.
    Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies
    Investigative Ophthalmology & Visual Science, 66, 5, 7. (2025).  
  • Vo P, Imai-Leonard DM, Yang B, Briere A, Shao A, Casanova MI, Adams D, Amano T, Amarie O, Berberovic Z, Bower L, Braun R, Brown S, Burrill S, Cho SY, Clementson-Mobbs S, D’Souza A, Dickinson M, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Heaney J, Hérault Y, Angelis MH, Hsu CW, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Meziane H, Murray S, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Ryan J, Salazar J, Seavey Z, Seavitt JR, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Stewart M, Svenson K, Tamura M, Tolentino H, Udensi U, Wells S, White J, Willett A, Wotton J, Wurst W, Yoshiki A; International Mouse Phenotyping Consortium; Lanoue L, Lloyd KCK, Leonard BC, Roux MJ, McKerlie C and Moshiri A.
    Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes
    EBMC Genomics 26, 1, 48. (2025).
  • Hayashi A, Kamio K, Miyanaga A, Yoshida K, Noro R, Matsuda K, Tozuka T,Omori M, Hirao M, Fukuizumi A, Hisakane K, Takeuchi S, Matsumoto M, Kasahara K,
    Amano T, Honda K and Seike M.
    “Ivermectin Enhances Paclitaxel Efficacy by Overcoming Resistance Through Modulation of ABCB1 in Non-small Cell Lung Cancer”
    Anticancer Research 44, (12) 5271-5282. (2024).
  • Saito A, Tahara R, Hirose M, Kadota M, Hasegawa A, Kondo S, Kato H, Amano T, Yoshiki A, Ogura A and Kiyosawa H.
    “Inter-subspecies mouse F1 hybrid embryonic stem cell lines newly established for studies of allelic imbalance in gene expression”
    Experimental Animals 24-0002. (2024).
  • Kawashima H, Nishimata S, Shinji S, Morishima Y, Tsutsumi N, Kashiwagi K, Amano T, Tamura M, Ayabe S and Nakashima K.
    “Three Siblings with Aarskog Scott Syndrome Together with Mental Retardation and Giant Megacolon”
    Glob. J. Pedia. 2, 1, IFN1000278. (2024).
  • Tada R+, Higashidate T+, Amano T, Ishikawa S, Yokoyama C, Kobari S, Nara S, Ishida K, Kawaguchi A, Ochi H, Ogino H, Yakushiji-Kaminatsui N, Sakamoto J,
    Kamei Y, Tamura K and Yokoyama A.
    “The shh limb enhancer is activated in patterned limb regeneration but not in hypomorphic limb regeneration in Xenopus laevis”
    Developmental Biology 500, 22-30. (2023).
    (+Authors equally contributed.)
  • Tanaka S, Orita H, Kataoka T, Miyazaki M, Saeki H, Wada R, Brock MV, Fukunaga T, Amano T, and Shiroishi T.
    “Gasdermin D Represses Inflammation-Induced Colon Cancer Development by Regulating Apoptosis”
    Carcinogenesis 44, 341–349. (2023).
  • Amano T.
    “Gene regulatory landscape of the sonic hedgehog locus in embryonic development”
    Dev. Growth Differ. 62, 334-342. (2020).
  • Sagai T, Amano T, Maeno A, Ajima R, and Shiroishi T.
    “SHH signaling mediated by a prechordal and brain enhancer controls forebrain organization”
    Proc. Natl. Acad. Sci. USA 116, 23636-23642. (2019).
  • Seo H+, Amano T+, Seki R, Sagai T, Kim J, Cho SW and Shiroishi T.
    “Upstream Enhancer Elements of Shh Regulate Oral and Dental Patterning.”
    J. Dent. Res. 97, 1055-1063. (2018).
    (+Authors equally contributed.)
  • Mouri K, Sagai T, Maeno A, Amano T, Toyoda A and Shiroishi T.
    “Enhancer Adoption Caused by Genomic Insertion Elicits Interdigital Shh Expression and Syndactyly in Mouse.”
    Proc. Natl. Acad. Sci. U. S. A. 115, 1021-1026. (2018).
  • Sagai T+, Amano T+, Maeno A, Kiyonari H, Seo H, Cho SW and Shiroishi T.
    “SHH Signaling Directed by Two Oral Epithelium-Specific Enhancers Controls Tooth and Oral Development.”
    Sci. Rep. 7, 13004. (2017).
    (+Authors equally contributed.)
  • Amano T, Sagai T, Seki R and Shiroishi T.
    “Two Types of Etiological Mutation in the Limb-Specific Enhancer of Shh.”
    G3 7, 2991-2998. (2017)
  • Sagai T, Amano T, Maeno A, Kimura T, Nakamoto M, Takehana Y, Naruse K, Okada N, Kiyonari H and Shiroishi T.
    “Evolution of Shh Endoderm Enhancers during Morphological Transition from Ventral Lungs to Dorsal Gas Bladder.”
    Nat. Commun. 3, 8:14300. (2017).
  • Tsukiji N+, Amano T+, and Shiroishi T.
    “A Novel Regulatory Element for Shh Expression in the Lung and Gut of Mouse Embryos.”
    Mech. Dev. 131, 127-136. (2014).
    (+Authors equally contributed.)
  • Tamura M, Hosoya M, Fujita M, Iida T, Amano T, Maeno A, Kataoka T, Otsuka T, Tanaka S, Tomizawa S and Shiroishi T.
    “Overdosage of Hand2 Causes Limb and Heart Defects in the Human Chromosomal Disorder Partial Trisomy Distal 4q.”
    Hum. Mol. Genet. 22, 2471-2481. (2013).
  • Yokoyama H, Maruoka T, Aruga A, Amano T, Ohgo S, Shiroishi T and Tamura K.
    “Prx-1 Expression in Xenopus laevis Scarless Skin-Wound Healing and Its Resemblance to Epimorphic Regeneration.”
    J Invest. Dermatol. 131, 2477-2485. (2011).
  • Sagai T, Amano T, Tamura M, Mizushina Y, Sumiyama K and Shiroishi T.
    “A Cluster of Three Long-Range Enhancers Directs Regional Shh Expression in the Epithelial Linings.”
    Development 136, 1665-1674. (2009).
  • Amano T, Sagai T, Tanabe H, Mizushina Y, Nakazawa H and Shiroishi T.
    “Chromosomal Dynamics at the Shh Locus: Limb Bud-Specific Differential Regulation of Competence and Active Transcription.”
    Dev. Cell 16, 47-57. (2009).

[和文]

  • 天野孝紀
    「遺伝子の発現制御はどこから」、遺伝学用語集 遺伝単、
    株式会社エヌ・ティー・エス、pp104-107、2017
  • 天野孝紀
    「第1章 2節 四倍体胚補完法を利用したCRISPR/Cas9ゲノム改変マウス胚の解析」、『進化するゲノム編集技術』、
    株式会社エヌ・ティー・エス、pp220-225、2015
  • 天野孝紀、城石俊彦
    「シーラカンスの鰭から四肢への進化を考える」生物の科学 遺伝、
    株式会社エヌ・ティー・エス、pp220-225、2014
  • 天野孝紀
    「マウスゲノムを読み解くための新しい文法書」
    生物の科学 遺伝、
    株式会社エヌ・ティー・エス、pp141-144、2013
  • 天野孝紀
    「第I部 生物機能モデルの作製と利用、第1章 発生・形態形成、第5節 中胚葉性器官形成、第4項 四肢」、『生物機能モデルと新しいリソース・リサーチツール』、
    株式会社エル・アイ・シー、pp121-127、2011

Next Generation Human Disease Model Research Team,

RIKEN BioResource Research Center

3-1-1 Koyadai, Tsukuba, Ibaraki, 305-0074, Japan

Mail: takanori.amano@riken.jp

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