This team was newly formed in July 2018. In order to elucidate onset mechanisms of intractable diseases, aging-associated diseases and lifestyle diseases, our team generates mouse models which recapitulate pathology of these human diseases. As a result of advances in next-generation sequencing (NGS) and genome-wide association studies (GWAS), a large amount of information about patient-derived genomes is accumulated. Patient-specific variants (mutations) have been identified as the potential cause of diseases. However, disease mechanisms by which the patient-specific variants develop diseases are mostly unknown. Our goal is to promote precise mouse modeling of human diseases, and to contribute realization of precision medicine and personalized medicine.