This team was newly formed in July 2018. In order to elucidate onset mechanisms of intractable diseases, aging-associated diseases and lifestyle diseases, our team generates mouse models which recapitulate pathology of these human diseases. As a result of advances in next-generation sequencing (NGS) and genome-wide association studies (GWAS), a large amount of information about patient-derived genomes is accumulated. Patient-specific variants (mutations) have been identified as the potential cause of diseases. However, disease mechanisms by which the patient-specific variants develop diseases are mostly unknown. Our goal is to promote precise mouse modeling of human diseases, and to contribute realization of precision medicine and personalized medicine.
We will establish POC (proof-of-concept) in preclinical studies. The disease model mice together with associated information useful for diagnosis, therapies and drug discovery will be distributed to the biomedical research community.