{"id":38,"date":"2018-11-02T16:37:45","date_gmt":"2018-11-02T07:37:45","guid":{"rendered":"http:\/\/hdm.brc.riken.jp\/ja\/?page_id=38"},"modified":"2025-08-22T14:51:43","modified_gmt":"2025-08-22T05:51:43","slug":"project","status":"publish","type":"page","link":"http:\/\/hdm.brc.riken.jp\/ja\/project","title":{"rendered":"\u30d7\u30ed\u30b8\u30a7\u30af\u30c8"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u25a0 \u814e\u75be\u60a3\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u958b\u767a\u3068\u75c5\u614b\u89e3\u6790<\/strong><\/strong><\/h4>\n\n\n\n<p>\u6162\u6027\u814e\u81d3\u75c5\uff08chronic kidney diseases, CKD\uff09\u306f\u65e5\u672c\u4eba\u306e\u7d0410\u4eba\u306b1\u4eba\u304c\u7f79\u60a3\u3059\u308b\u3068\u3044\u308f\u308c\u308b\u56fd\u6c11\u7684\u75be\u60a3\u3067\u3042\u308a\u3001\u9032\u884c\u3059\u308b\u3068\u900f\u6790\u7642\u6cd5\u304c\u5fc5\u8981\u306a\u814e\u4e0d\u5168\u3078\u3068\u81f3\u308a\u307e\u3059\u3002\u56fd\u5185\u306e\u900f\u6790\u60a3\u8005\u306f\u7d0434\u4e07\u4eba\u306b\u306e\u307c\u308a\uff082022\u5e74\u6642\u70b9\uff09\u3001\u793e\u4f1a\u4fdd\u969c\u8cbb\u306e\u8ca0\u62c5\u3082\u5927\u304d\u304f\u3001CKD\u306f\u533b\u7642\u30fb\u7d4c\u6e08\u306e\u4e21\u9762\u3067\u6df1\u523b\u306a\u793e\u4f1a\u8ab2\u984c\u3067\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u65e9\u671f\u8a3a\u65ad\u30fb\u9032\u884c\u6291\u5236\u30fb\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u6025\u52d9\u3067\u3059\u3002\u5f93\u6765\u3001CKD\u306e\u4e3b\u306a\u539f\u56e0\u306f\u9ad8\u8840\u5727\u3084\u7cd6\u5c3f\u75c5\u3068\u3044\u3063\u305f\u751f\u6d3b\u7fd2\u6163\u75c5\u3068\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u8fd1\u5e74\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u907a\u4f1d\u7684\u306a\u8981\u56e0\u3082\u5f37\u304f\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u6027\u814e\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u30d0\u30ea\u30a2\u30f3\u30c8\u304cCKD\u306b\u7f79\u60a3\u3057\u305f\u60a3\u8005\u30b2\u30ce\u30e0\u306b\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u3001\u3053\u308c\u3089\u306fCKD\u306e\u300c\u6f5c\u5728\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u300d\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5f53\u30c1\u30fc\u30e0\u3067\u306f\u3001\u3053\u306e\u907a\u4f1d\u6027\u814e\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u6f5c\u5728\u7684\u306a\u30ea\u30b9\u30af\u306b\u7740\u76ee\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u3053\u308c\u307e\u3067\u5e0c\u5c11\u75be\u60a3\u3068\u3055\u308c\u3066\u304d\u305f\u907a\u4f1d\u6027\u814e\u75be\u60a3\u306e\u7814\u7a76\u304c\u3001\u3088\u308a\u4e00\u822c\u7684\u306aCKD\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u3082\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304b\u3089\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u3053\u3067\u79c1\u305f\u3061\u306f\u3001\u60a3\u8005\u7279\u7570\u7684\u306a\u30d0\u30ea\u30a2\u30f3\u30c8\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\uff08CRISPR\/Cas9\uff09\u3092\u7528\u3044\u3066\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u958b\u767a\u3057\uff08\u56f3\uff11\uff09\u3001\u814e\u81d3\u306e\u75c5\u7406\u7d44\u7e54\u89e3\u6790\u30fb\u5c3f\u3084\u8840\u6db2\u306e\u691c\u67fb\u30fb\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u306a\u3069\u3092\u901a\u3058\u3066\u3001\u75be\u60a3\u767a\u75c7\u3084\u9032\u884c\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\uff08\u56f3\uff12\uff09\u3002\u307e\u305f\u3001\u75c5\u614b\u518d\u73fe\u5ea6\u306e\u9ad8\u3044\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306b\u95a2\u3057\u3066\u306f\u3001\u81e8\u5e8a\u7814\u7a76\u8005\u3068\u306e\u9023\u643a\u306e\u3082\u3068\u5275\u85ac\u7814\u7a76\u3078\u3068\u5c55\u958b\u3057\u3001\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u5411\u3051\u305f\u524d\u81e8\u5e8a\u57fa\u76e4\u306e\u69cb\u7bc9\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-snow-monkey-blocks-items smb-items\"><div class=\"c-row c-row--margin c-row--center\" data-columns=\"1\" data-md-columns=\"2\" data-lg-columns=\"2\">\n<div class=\"wp-block-snow-monkey-blocks-items-item-free c-row__col\"><div class=\"smb-items__item smb-items__item--free\"><div class=\"smb-items__item__body is-layout-constrained wp-block-snow-monkey-blocks-items-item-free-is-layout-constrained\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/hdm.brc.riken.jp\/ja\/wp-content\/uploads\/projectImage01.png\" alt=\"\" class=\"wp-image-889\" style=\"aspect-ratio:4\/3;object-fit:contain;width:auto;height:300px\"\/><\/figure>\n<\/div>\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><em>\u56f3\uff11\uff1aCRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u305f\u30b2\u30ce\u30e0\u7de8\u96c6\u30de\u30a6\u30b9\u306e\u4f5c\u88fd\u6982\u8981\u3002\u30ac\u30a4\u30c9RNA\u306b\u8a98\u5c0e\u3055\u308c\u305fCas9\u9175\u7d20\u304c\u6a19\u7684\u3068\u3059\u308b\u907a\u4f1d\u5b50\u914d\u5217\u3092\u5207\u65ad\u3059\u308b\u3002\u5207\u65ad\u4fee\u5fa9\u6642\u306b\u75be\u60a3\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6709\u3059\u308bDNA\u914d\u5217\u304c\u53d6\u308a\u8fbc\u307e\u308c\u3001\u30de\u30a6\u30b9\u306b\u30ce\u30c3\u30af\u30a4\u30f3\u3055\u308c\u308b\u3002<\/em><\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-snow-monkey-blocks-items-item-free c-row__col\"><div class=\"smb-items__item smb-items__item--free\"><div class=\"smb-items__item__body is-layout-constrained wp-block-snow-monkey-blocks-items-item-free-is-layout-constrained\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/hdm.brc.riken.jp\/ja\/wp-content\/uploads\/projectImage02.png\" alt=\"\" class=\"wp-image-890\" style=\"aspect-ratio:4\/3;object-fit:contain;width:auto;height:300px\"\/><\/figure>\n<\/div>\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><em>\u56f3\uff12\uff1a\u30de\u30a6\u30b9\u814e\u7cf8\u7403\u4f53\u306e\u75c5\u7406\u7d44\u7e54\u89e3\u6790\u3002HE\uff08\u30d8\u30de\u30c8\u30ad\u30b7\u30ea\u30f3\u30fb\u30a8\u30aa\u30b8\u30f3\uff09\u67d3\u8272\u3001PAM\u67d3\u8272\u3001Masson&#8217;s Trichrome\u67d3\u8272\u3001PAS\u67d3\u8272\u7b49\u306b\u3088\u308a\u3001\u7cf8\u7403\u4f53\u57fa\u5e95\u819c\u306e\u69cb\u9020\u3001\u30e1\u30b5\u30f3\u30ae\u30a6\u30e0\u7d30\u80de\u306e\u5897\u6b96\u3001\u7d44\u7e54\u306e\u7dda\u7dad\u5316\u3092\u8a55\u4fa1\u3059\u308b\u3002<\/em><\/p>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u25a0 ALS\u75c5\u614b\u306b\u95a2\u308f\u308b<em>Tardbp<\/em> 3\u2032UTR \u306e\u767a\u73fe\u5236\u5fa1\u6a5f\u69cb<\/strong><\/strong><\/h4>\n\n\n\n<p>\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u306f\u3001\u968f\u610f\u904b\u52d5\u3092\u53f8\u308b\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u9078\u629e\u7684\u306b\u969c\u5bb3\u3055\u308c\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3059\uff08\u56f33\uff09\u3002\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u55aa\u5931\u306b\u3088\u308a\u3001\u7b4b\u529b\u4f4e\u4e0b\u3001\u9ebb\u75fa\u3001\u3055\u3089\u306b\u306f\u547c\u5438\u4e0d\u5168\u3078\u3068\u9032\u884c\u3057\u307e\u3059\u3002ALS\u306e\u60a3\u8005\u3055\u3093\u306e\u307b\u3068\u3093\u3069\uff0890\u301c95\uff05\uff09\u306f\u5bb6\u65cf\u6b74\u304c\u306a\u304f\u3001\u660e\u78ba\u306a\u907a\u4f1d\u5b50\u5909\u7570\u304c\u898b\u3064\u304b\u3089\u306a\u3044\u6563\u767a\u6027\uff08sporadic\uff09\u306e\u30b1\u30fc\u30b9\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u907a\u4f1d\u5b50\u5909\u7570\u3092\u3082\u3068\u306b\u3057\u305f\u75c5\u6c17\u306e\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u4f5c\u308b\u3053\u3068\u304c\u96e3\u3057\u304f\u3001\u7814\u7a76\u306b\u304a\u3051\u308b\u75c5\u614b\u306e\u518d\u73fe\u304c\u9650\u5b9a\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001TDP-43\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d30\u80de\u8cea\u3078\u306e\u7570\u5e38\u306a\u51dd\u96c6\u306f\u3001\u907a\u4f1d\u80cc\u666f\u306b\u95a2\u308f\u3089\u305a97\uff05\u4ee5\u4e0a\u306eALS\u60a3\u8005\u3067\u5171\u901a\u3057\u3066\u307f\u3089\u308c\u308b\u75c5\u7406\u7684\u7279\u5fb4\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5171\u901a\u6027\u306e\u9ad8\u3044\u5206\u5b50\u7570\u5e38\u306b\u7740\u76ee\u3057\u3001\u79c1\u305f\u3061\u306f\u305d\u306e\u767a\u73fe\u91cf\u3092\u8abf\u7bc0\u3059\u308b\u4ed5\u7d44\u307f\u306b\u6ce8\u76ee\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>TDP-43\u306e\u30b3\u30fc\u30c9\u907a\u4f1d\u5b50\uff08<em>Tardbp<\/em>\uff09\u306e3\u2032\u975e\u7ffb\u8a33\u9818\u57df\uff083\u2032UTR\uff09\u306b\u306f\u3001\u8907\u6570\u306e\u30dd\u30ea\u30a2\u30c7\u30cb\u30eb\u5316\u30b7\u30b0\u30ca\u30eb\u3084\u3001TDP-43\u81ea\u8eab\u304c\u7d50\u5408\u3057\u3066\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u5236\u5fa1\u3059\u308b\u9818\u57df\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u3053\u306e\u9818\u57df\u304cTDP-43\u306e\u767a\u73fe\u5236\u5fa1\u306b\u679c\u305f\u3059\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u30013\u2032UTR\u306e\u4e00\u90e8\u3092\u6b20\u5931\u3055\u305b\u305f\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u4f5c\u88fd\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u6b20\u5931\u306b\u3088\u308a\u3001\u30db\u30e2\u63a5\u5408\u4f53\u30de\u30a6\u30b9\u80da\u306f\u539f\u8178\u5f62\u6210\u671f\u3067\u80da\u767a\u751f\u304c\u505c\u6b62\u3057\u3066\u81f4\u6b7b\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001<em>Tardbp<\/em> mRNA\u306e\u767a\u73fe\u304c\u5927\u304d\u304f\u4f4e\u4e0b\u3057\u305f\u3053\u3068\u306b\u3088\u308b\u3082\u306e\u3067\u3059\u3002\u3055\u3089\u306b\u3001\u52a0\u9f62\u3057\u305f\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u30de\u30a6\u30b9\u3067\u306f\u3001\u810a\u9ac4\u306b\u304a\u3051\u308bTDP-43\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5897\u52a0\u3001\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6e1b\u5c11\u3001\u8efd\u5ea6\u306e\u904b\u52d5\u6a5f\u80fd\u969c\u5bb3\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\uff08\u56f34\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001<em>Tardbp<\/em>\u306e3\u2032UTR\u306b\u5b58\u5728\u3059\u308b\u5236\u5fa1\u914d\u5217\u306f\u6b63\u5e38\u767a\u751f\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3068\u540c\u6642\u306b\u3001TDP-43\u306b\u95a2\u9023\u3059\u308bALS\u75c5\u614b\u306b\u3082\u95a2\u4e0e\u3057\u3046\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-snow-monkey-blocks-items smb-items\"><div class=\"c-row c-row--margin c-row--center\" data-columns=\"1\" data-md-columns=\"2\" data-lg-columns=\"2\">\n<div class=\"wp-block-snow-monkey-blocks-items-item-free c-row__col\"><div class=\"smb-items__item smb-items__item--free\"><div class=\"smb-items__item__body is-layout-constrained wp-block-snow-monkey-blocks-items-item-free-is-layout-constrained\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/hdm.brc.riken.jp\/ja\/wp-content\/uploads\/projectImage03.png\" alt=\"\" class=\"wp-image-893\" style=\"aspect-ratio:4\/3;object-fit:contain;width:auto;height:300px\"\/><\/figure>\n<\/div>\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><em>\u56f3\uff13\uff1a\u795e\u7d4c\u5909\u6027\u75be\u60a3\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u4f5c\u88fd\u3068\u75c5\u614b\u8a55\u4fa1<\/em><\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-snow-monkey-blocks-items-item-free c-row__col\"><div class=\"smb-items__item smb-items__item--free\"><div class=\"smb-items__item__body is-layout-constrained wp-block-snow-monkey-blocks-items-item-free-is-layout-constrained\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/hdm.brc.riken.jp\/ja\/wp-content\/uploads\/projectImage04.png\" alt=\"\" class=\"wp-image-894\" style=\"aspect-ratio:4\/3;object-fit:contain;width:auto;height:300px\"\/><\/figure>\n<\/div>\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><em>\u56f3\uff14\uff1aALS\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u810a\u9ac4\u306b\u304a\u3051\u308b\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6e1b\u5c11\u3002\u91ce\u751f\u578b (A)\u3068ALS\u30e2\u30c7\u30eb (B)\u306e\u810a\u9ac4\u5207\u7247\u306b\u304a\u3051\u308bKB\u67d3\u8272\u3002(C, D) \u810a\u9ac4\u306eChAT\u306e\u767a\u73fe\uff08\u30de\u30bc\u30f3\u30bf\uff09\u3068DAPI\u306b\u3088\u308b\u6838\u67d3\u8272\uff08\u9752\uff09\u3002(E)\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u6570\u306e\u5b9a\u91cf\u8a55\u4fa1\u3002<\/em><\/p>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u25a0 \u30de\u30a6\u30b9\u4e9c\u7a2e\u3092\u5229\u7528\u3057\u305f\u907a\u4f1d\u7684\u591a\u69d8\u6027\u306e\u89e3\u6790<\/strong><\/strong><\/h4>\n\n\n\n<p>\u30d2\u30c8\u306e\u75be\u60a3\u767a\u75c7\u306b\u306f\u3001\u751f\u6d3b\u7fd2\u6163\u3084\u74b0\u5883\u8981\u56e0\u306b\u52a0\u3048\u3001\u30b2\u30ce\u30e0\u914d\u5217\u306e\u9055\u3044\uff08\u30d0\u30ea\u30a2\u30f3\u30c8\uff09\u304c\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u708e\u75c7\u3084\u611f\u67d3\u9632\u5fa1\u306b\u95a2\u308f\u308b\u514d\u75ab\u7d30\u80de\u3067\u306f\u3001\u907a\u4f1d\u7684\u80cc\u666f\u306b\u3088\u3063\u3066\u7d30\u80de\u5fdc\u7b54\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u7406\u89e3\u306f\u500b\u5225\u5316\u533b\u7642\u3084\u5275\u85ac\u306b\u304a\u3044\u3066\u5927\u304d\u306a\u610f\u5473\u3092\u3082\u3061\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5b9f\u9a13\u52d5\u7269\u3067\u3042\u308b\u30de\u30a6\u30b9\u306e\u7814\u7a76\u306f\u901a\u5e38\u3001\u57fa\u6e96\u3068\u306a\u308b\u7d14\u7cfb\u7cfb\u7d71\uff08\u305f\u3068\u3048\u3070C57BL\/6\u7cfb\u7d71\uff09\u306b\u4f9d\u5b58\u3057\u3066\u304a\u308a\u3001\u30d2\u30c8\u306e\u3088\u3046\u306a\u907a\u4f1d\u7684\u591a\u69d8\u6027\u3092\u53cd\u6620\u3055\u305b\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u5f53\u30c1\u30fc\u30e0\u3067\u306f\u3001RIKEN BRC\u304c\u4fdd\u6709\u3059\u308b\u57fa\u6e96\u7cfb\u7d71\u7b49\u3068\u907a\u4f1d\u7684\u306b\u96e2\u308c\u305f\u30de\u30a6\u30b9\u4e9c\u7a2e\u2014Mus musculus molossinus\u7531\u6765\u306eJF1\u7cfb\u7d71\u2014\u3092\u6d3b\u7528\u3057\u3066\u3001\u907a\u4f1d\u7684\u80cc\u666f\u304c\u500b\u4f53\u306e\u6027\u8cea\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\uff08\u56f35\uff09\u3002C57BL\/6 (B6)\u3068JF1\u306e\u4ea4\u914d\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u305fF1\u96d1\u7a2e\u3067\u306f\u3001\u4e21\u89aa\u7531\u6765\u306e\u30a2\u30ec\u30eb\u304c\u540c\u4e00\u7d30\u80de\u5185\u306b\u5171\u5b58\u3059\u308b\u305f\u3081\u3001\u907a\u4f1d\u7684\u306a\u767a\u73fe\u5236\u5fa1\u306e\u9055\u3044\u3092\u76f4\u63a5\u6bd4\u8f03\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff08\u56f36\uff09\u3002\u672c\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u5bfe\u8c61\u3068\u3057\u305fRNA-seq\u89e3\u6790\u306b\u3088\u308a\u3001\u514d\u75ab\u5fdc\u7b54\u3084\u4ee3\u8b1d\u7d4c\u8def\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u7fa4\u3067\u30a2\u30ec\u30eb\u7279\u7570\u7684\u306a\u767a\u73fe\u5dee\u304c\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u7279\u306b\u3001\u89e3\u7cd6\u7cfb\u9175\u7d20\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u907a\u4f1d\u5b50\u306b\u9855\u8457\u306a\u30a2\u30ec\u30eb\u7279\u7570\u7684\u767a\u73fe\u304c\u89b3\u5bdf\u3055\u308c\u3066\u304a\u308a\u3001\u514d\u75ab\u6d3b\u6027\u3084\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6975\u6027\u5316\u306b\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30a2\u30ec\u30eb\u767a\u73fe\u5dee\u304c\u69cb\u9020\u591a\u578b\uff08SV\uff09\u3068\u8fd1\u63a5\u3057\u3066\u3044\u308b\u50be\u5411\u3082\u78ba\u8a8d\u3055\u308c\u3001SINE\u3084LINE\u3068\u3044\u3063\u305f\u53cd\u5fa9\u914d\u5217\u306e\u5b58\u5728\u304c\u30a2\u30ec\u30eb\u3054\u3068\u306e\u767a\u73fe\u5236\u5fa1\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u5f8c\u306f\u3001\u4ed6\u306e\u514d\u75ab\u7d30\u80de\u3084\u7d44\u7e54\u306b\u3082\u5bfe\u8c61\u3092\u62e1\u5f35\u3057\u3001\u75be\u60a3\u30ea\u30b9\u30af\u3068\u907a\u4f1d\u7684\u591a\u69d8\u6027\u306e\u95a2\u4fc2\u89e3\u660e\u3001\u3055\u3089\u306b\u306f\u500b\u5225\u5316\u6cbb\u7642\u306e\u57fa\u76e4\u69cb\u7bc9\u3078\u3068\u3064\u306a\u3052\u3066\u3044\u304f\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u5b9f\u9a13\u30de\u30a6\u30b9\u306f\u4e3b\u306bB6\u7cfb\u7d71\u304c\u7528\u3044\u3089\u308c\u307e\u3059\u304c\u3001\u7570\u306a\u308b\u30de\u30a6\u30b9\u4e9c\u7a2e\uff08\u4f8b\uff1aJF1\u3001MSM\uff09\u3068\u306e\u4ea4\u914d\u306b\u3088\u308a\u3001\u30b2\u30ce\u30e0\u914d\u5217\u306e\u591a\u69d8\u6027\u3092\u6d3b\u7528\u3057\u305f\u89e3\u6790\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u5f53\u30c1\u30fc\u30e0\u3067\u306f\u3001\u7570\u306a\u308b\u4e9c\u7a2e\u7531\u6765\u306eF1\u96d1\u7a2e\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u3001\u30a2\u30ec\u30eb\u7279\u7570\u7684\u907a\u4f1d\u5b50\u767a\u73fe\uff08ASE\uff09\u89e3\u6790\u3084\u95a2\u9023\u3059\u308b\u30b2\u30ce\u30e0\u591a\u578b\u306e\u540c\u5b9a\u3092\u884c\u3044\u3001\u8868\u73fe\u578b\u591a\u69d8\u6027\u306e\u539f\u56e0\u3068\u306a\u308b<em>cis<\/em>\u8abf\u7bc0\u56e0\u5b50\u306e\u540c\u5b9a\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-snow-monkey-blocks-items smb-items\"><div class=\"c-row c-row--margin c-row--center\" data-columns=\"1\" data-md-columns=\"2\" data-lg-columns=\"2\">\n<div class=\"wp-block-snow-monkey-blocks-items-item-free c-row__col\"><div class=\"smb-items__item smb-items__item--free\"><div class=\"smb-items__item__body is-layout-constrained wp-block-snow-monkey-blocks-items-item-free-is-layout-constrained\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/hdm.brc.riken.jp\/ja\/wp-content\/uploads\/projectImage05-e1753431143514.png\" alt=\"\" class=\"wp-image-895\" style=\"aspect-ratio:4\/3;object-fit:contain;width:auto;height:300px\"\/><\/figure>\n<\/div>\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><em>\u56f3\uff15\uff1a\u30de\u30a6\u30b9\u306e\u4e9c\u7a2e\u7cfb\u7d71\u3002Mus.musculus domesticus\u306f\u3001\u897f\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u91ce\u751f\u7a2e\u3092\u8d77\u6e90\u3068\u3057\u3001Mus.musculus molossinus\u306f\u3001\u6771\u30a2\u30b8\u30a2\u306e\u91ce\u751f\u7a2e\u3092\u8d77\u6e90\u3068\u3059\u308b\u3002<\/em><\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-snow-monkey-blocks-items-item-free c-row__col\"><div class=\"smb-items__item smb-items__item--free\"><div class=\"smb-items__item__body is-layout-constrained wp-block-snow-monkey-blocks-items-item-free-is-layout-constrained\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/hdm.brc.riken.jp\/ja\/wp-content\/uploads\/projectImage06-e1753431110683.png\" alt=\"\" class=\"wp-image-896\" style=\"aspect-ratio:4\/3;object-fit:contain;width:auto;height:300px\"\/><\/figure>\n<\/div>\n\n\n<div style=\"height:16px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><em>\u56f3\uff16\uff1aF1\u96d1\u7a2e\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u30a2\u30ec\u30eb\u7279\u7570\u7684\u767a\u73fe\u89e3\u6790\u3002\u5171\u901a\u306e\u8ee2\u5199\u56e0\u5b50\u74b0\u5883\u4e0b\u3067\u3001B6\u3068JF1\u7531\u6765\u306e\u30a2\u30ec\u30eb\u306e\u767a\u73fe\u91cf\u3092\u8ee2\u5199\u7523\u7269\u306eSNPs\u3092\u57fa\u306b\u6bd4\u8f03\u3057\u3066\u30a2\u30ec\u30eb\u7279\u7570\u7684\u306a\u767a\u73fe\u5dee\u3092\u8a55\u4fa1\u3059\u308b\u3002<\/em><\/p>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u30d7\u30ed\u30b8\u30a7\u30af\u30c8 \u25a0 \u814e\u75be\u60a3\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u958b\u767a\u3068\u75c5\u614b\u89e3\u6790 \u6162\u6027\u814e\u81d3\u75c5\uff08chronic kidney diseases, CKD\uff09\u306f\u65e5\u672c\u4eba\u306e\u7d0410\u4eba\u306b1\u4eba\u304c\u7f79\u60a3\u3059\u308b\u3068 &#8230; <\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-38","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"http:\/\/hdm.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/38","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/hdm.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/hdm.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/hdm.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/hdm.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=38"}],"version-history":[{"count":3,"href":"http:\/\/hdm.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/38\/revisions"}],"predecessor-version":[{"id":411,"href":"http:\/\/hdm.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/38\/revisions\/411"}],"wp:attachment":[{"href":"http:\/\/hdm.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=38"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}